Yuanzhe Zhou (周源哲)


My primary research interests are computational modeling of RNA-targeted drug discovery. My recent projects are focused on developing data-driven machine learning and optimization algorithms to elucidate complex relationships between upon ligand binding. I obtained my Ph.D. in Physics from the University of Missouri - Columbia in 2021 under the supervision of Prof. Shi-Jie Chen and worked as a postdoctoral fellow in Prof. Shi-Jie Chen's lab until June 2025.
Research Interests

RNA-ligand/metal ion interaction
RNA-targeted small molecule virtual screening/drug discovery
Major Projects (More Description)

☆ RLDOCKScore, a physics-based scoring function for RNA-ligand binding mode prediction and virtual screening

☆ SPRank, a statistical potential-based scoring function for RNA-ligand binding mode prediction and virtual screening

☆ MgNet, a convolutional neural network (CNN) model for predicting Mg2+ binding sites in RNAs
Education

PhD in Physics, University of Missouri - Columbia, Columbia, USA, 2021
BS in Physics, Southern University of Science and Technology (SUSTech), Shenzhen, China, 2016

© Yuanzhe Zhou,